Table 5 Assessment of associations between colorectal cancer risk and each of the three at-risk alleles of SNPsa in patients with CRC diagnosed before 51 years of age or advanced colorectal adenoma before 41 years of age

From: Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

Locus

Genotype

Controls (N=350), no. (%)

Patients (N=887), no. (%)

P-value b

Odds ratio c

95% Confidence interval c

8q23.3

      

 Rs16892766

      
 

AA

311 (88.8)

711 (80.2)

 

1

 
 

CA and CC

39 (11.2)

176 (19.8)

0.0004**

1.97

1.36–2.86

15q13.3

      

 Rs4779584

      
 

CC

223 (63.7)

481 (54.2)

 

1

 
 

TC and TT

127 (36.3)

406 (45.8)

0.0036**

1.46

1.13–1.89

18q21.1

      

 Rs58920878/Novel 1

      
 

CC

110 (31.4)

210 (23.7)

 

1

 
 

GC and GG

240 (68.6)

676 (76.3)

0.0045**

1.49

1.13–1.96

  1. Bold-type figures correspond to P<0.05; **P<0.0167 (significance threshold according to Bonferroni's correction for multiple testing with three SNPs tested).
  2. Rs16892766 on 8q23.3, rs4779584 on 15q13.3 and rs58920878/Novel 1 on 18q21.1.
  3. bAccording to Pearson's χ2 test.
  4. cEstimated from unconditional logistic regression with case–control status as the response and with adjustment for sex.
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