Table 6 Assessment of associations between colorectal tumour risk and the number of at-risk alleles or genotypes at the 8q23.3, 15q13.3 and 18q21.1 loci

From: Clinical relevance of 8q23, 15q13 and 18q21 SNP genotyping to evaluate colorectal cancer risk

 

Controls (N=350), no. (%)

Patients (N=1028), no. (%)

P-value a (trend test)

Odds ratio b

95% Confidence b interval

Number of at-risk alleles

 0

60 (17.1)

95 (9.2)

 

1

 

 1

131 (37.4)

335 (32.6)

 

1.62

1.10–2.37

 2

117 (33.4)

391 (38.0)

<0.0001

2.09

1.43–3.07

 3

34 (9.7)

157 (15.3)

 

2.87

1.76–4.70

 ≥4c

8 (2.3)

50 (4.9)

 

3.88

1.72–8.76

Number of at-risk genotypes

 0

60 (17.1)

95 (9.2)

 

1

 

 1

181 (51.7)

489 (47.6)

 

1.71

1.18–2.46

 2

102 (29.1)

374 (36.4)

<0.0001

2.29

1.55–3.38

 3

7 (2.1)

70 (6.8)

 

6.21

2.67–14.42

  1. Bold-type figures correspond to P<0.0001 using the Cochran-Armitage test of trend.
  2. aAccording to Pearson's χ2 test.
  3. bEstimated from unconditional logistic regression with case/control status as the response and with adjustment for sex.
  4. cCorresponding to 4 or 5 at-risk alleles.
Back to article page