Table 1 Eleven of the 57 independent previously reported coeliac disease signals were nominally significant in the Irish sample

From: Common polygenic variation in coeliac disease and confirmation of ZNF335 and NIFA as disease susceptibility loci

Chromosome

Variant ID

Allele

MAF IRISH

OR Irish

PIrish

OR Trynka

PTrynka

Nearest gene

4

rs13132308:g.123770564A>G

G

0.1686

0.614

7.45E-04

0.7054

1.87E-38

ADAD1, IL2, IL21, KIAA1109

18

rs11875687:g.12833137T>C

C

0.1899

1.527

1.87E-03

1.173

1.92E-10

PTPN2

3

rs76830965:g.161120372C>A

A

0.1595

1.547

3.06E-03

1.36

2.56E-27

SCHIP1, IL12A

12

rs3184504:g.110368991T>C

T

0.4914

1.391

3.41E-03

1.192

5.42E-21

ATXN2, SH2B3

11

rs61907765:g.127897147C>T

T

0.2175

1.459

3.69E-03

1.175

3.43E-13

ETS1

6

rs1107943:g.159418255T>C

C

0.07062

1.819

6.31E-03

1.221

7.95E-09

TAGAP

8

rs10808568:g.129333242A>C

C

0.2472

0.7258

1.03E-02

0.9132

2.20E-05

PVT1

11

rs10892258:g.118085075G>A

A

0.2275

0.7165

1.11E-02

0.8611

1.73E-11

DDX6, TREH

1

rs72657048:g.25162321C>G

C

0.4525

0.777

2.26E-02

0.918

3.79E-06

RUNX3

4

rs62323881:g.123257745A>G

A

0.07973

1.568

2.98E-02

1.204

6.87E-08

ADAD1, IL2, IL21, KIAA1109

1

rs1359062:g.190808095C>G

C

0.1775

0.7605

5.00E-02

0.7691

2.55E-25

RGS1

  1. All genomic locations are based on human genome build 18.
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