Table 1 Biometric characteristics and dose of study medication

From: Is there an effect of intranasal insulin on development and behaviour in Phelan-McDermid syndrome? A randomized, double-blind, placebo-controlled trial

 

Body

Cranial

 

Dose based on

 

Age

weight a

volume b

Dose

Weight

Volume

Administration

(years)

(kg)

litres (l)

IU/day

IU/kg/day

IU/l/day

no of sprays c

1–3

10–15

1.0–1.1

20

1.3–2.0

18.2–20.0

2 dd 1

3–9

15–30

1.1–1.25

30

1.0–2.0

24.0–27.3

1 dd 2 + 1 dd 1

9–18

30–65

1.25–1.5

40

0.6–1.3

26.7–32.0

2 dd 2

  1. aEstimated body weight (based on ref. 18).
  2. bEstimated cranial volume (ref. 19).
  3. cOne nasal spray is 0.1 ml and contains 10 IU.
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