Table 1 Patient characteristics exome sequencing cohort
Subject (UPN) | Country of inclusion | Age at diagnosis GC | Family history of GC | Criterium a | GC histology reviewed | Lauren | WHO | GC histology original pathology reports | Histology of GC cases in family | Other remarks |
|---|---|---|---|---|---|---|---|---|---|---|
005A | The Netherlands | 50 | FDR DGC 50, FDR GC 48 | 3 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
018A | The Netherlands | 26 | SDR GC 27, TDR GC 55 | 3 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
023A | The Netherlands | 43 | FDR DGC 58 | 2 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
025A | The Netherlands | 32 | No | 1 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
036A | The Netherlands | 23 | No | 1 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | Consanguineous |
042A | The Netherlands | 35 | FDR GC 50 | 2 | No | Diffuse (poorly cohesive) | DGC | |||
049A | The Netherlands | 66 | FDR IGC 54, FDR GC 60, SDR IGC 83, SDR GC 50, SDR GC 58, SDR GC 60 | 3 | Yes | Intestinal | Tubular | Intestinal (tubular) | IGC | |
059A | The Netherlands | 35 | FDR DGC 51, FDR GC 22, FDR GC 42 | 3 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
059B | The Netherlands | 51 | FDR DGC 35, FDR GC 22, FDR GC 42 | 3 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
107A | The Netherlands | 69 | FDR GC 57, FDR GC 66, FDR GC 72, FDR GC 81 | 3 | Yes | Intestinal | Tubular | Not specified ‘adenocarcinoma’ | IGC | |
112A | The Netherlands | 34 | No | 1 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
119A | The Netherlands | 31 | No | 1 | Yes | Intestinal | Tubular | Intestinal (tubular) | IGC | |
120A | The Netherlands | 31 | No | 1 | Yes | Intestinal | Tubular | Not specified ‘adenocarcinoma’ | IGC | Consanguineous |
121A | The Netherlands | 27 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
124A | The Netherlands | 54 | FRD IGC 51, FDR IGC 53, TDR IGC 55, TDR GC 35 | 3 | Yes | Intestinal | Mucinous | Intestinal (mucinous) | IGC | |
125A | The Netherlands | 33 | FDR DGC 56 | 2 | No | Diffuse (poorly cohesive) | DGC | |||
135A | The Netherlands | 46 | FDR GC 52 | 2 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | Patient also had ductal breast carcinoma at age 51 |
162A | The Netherlands | 33 | FDR IGC 42 | 2 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | Combined DGC and IGC | |
164A | The Netherlands | 36 | No | 1 | Yes | Diffuse | Poorly cohesive | Not specified ‘adenocarcinoma’ | DGC | |
167A | The Netherlands | 31 | No | 1 | Yes | Diffuse | Poorly cohesive | Diffuse (poorly cohesive) | DGC | |
509A | Portugal | 49 | FDR GC, SDR GC, SDR GC | 3 | No | Diffuse (poorly cohesive) | DGC | |||
510A | Portugal | 41 | FDR DGC 21, FDR DGC 40 | 3 | No | Diffuse (poorly cohesive) | DGC | |||
511A | Portugal | 34 | SDR DGC 54 | 2 | No | Diffuse (poorly cohesive) | DGC | |||
512A | Portugal | 48 | FDR DGC, SDR DGC | 3 | No | Diffuse (poorly cohesive) | DGC | |||
513A | Portugal | 30 | Familial history of DGC, incomplete information | 1 | No | Diffuse (poorly cohesive) | DGC | |||
516A | Germany | 29 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
520A | Germany | 28 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
521A | Germany | 43 | FDR GC 47 | 2 | No | Intestinal (tubular) | IGC | |||
522A | Germany | 23 | No | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
529A | Italy | 34 | SDR GC 41 | 2 | No | Not specified ‘adenocarcinoma’ | AC | |||
530A | Italy | 30 | No | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
531A | Italy | 34 | No | 1 | No | Diffuse (poorly cohesive) | DGC | Patient also had basal cell carcinoma at age 42 and DGC 53 | ||
532A | Italy | 30 | No | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
701A | Poland | 22 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
703A | Poland | 68 | FDR GC 42, FDR GC 65 | 3 | No | Not specified ‘adenocarcinoma’ | AC | |||
711A | Poland | 49 | FDR GC 46 | 2 | No | Intestinal (mucinous) | IGC | |||
716A | Poland | 45 | FDR GC 50 | 2 | No | Intestinal (tubular) | IGC | |||
725A | Poland | 38 | FDR GC 50, SDR GC 56 | 3 | No | Not specified ‘adenocarcinoma’ | AC | |||
727A | Poland | 42 | FDR GC 50, SDR GC 56 | 3 | No | Not specified ‘adenocarcinoma’ | AC | |||
729A | Poland | 48 | FDR GC 40, FDR GC 79 | 3 | No | Intestinal (tubular) | IGC | Patient also had liver cancer age 50 | ||
730A | Poland | 29 | SDR GC 35 | 2 | No | Intestinal (tubular) | IGC | |||
731A | Poland | 28 | No | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
733A | Poland | 70 | FDR GC 52, FDR GC 62 | 3 | No | Not specified ‘adenocarcinoma’ | AC | |||
741A | Poland | 29 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
743A | Poland | 25 | FDR GC 49 | 2 | No | Not specified ‘adenocarcinoma’ | AC | |||
755A | Poland | 30 | No | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
756A | Poland | 50 | FDR GC 48 | 2 | No | Mixed | Mixed | |||
759A | Poland | 25 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
760A | Poland | 30 | FDR GC 70, SDR GC<75, SDR GC<75 | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
762A | Poland | 32 | FDR GC 46 | 2 | No | Not specified ‘adenocarcinoma’ | AC | |||
763A | Poland | 45 | FDR GC 40 | 2 | No | Not specified ‘adenocarcinoma’ | AC | |||
772A | Poland | 34 | No | 1 | No | Not specified ‘adenocarcinoma’ | AC | |||
774A | Poland | 33 | No | 1 | No | Diffuse (poorly cohesive) | DGC | |||
780A | Poland | 36 | FDR GC 39 | 2 | No | Diffuse (poorly cohesive) | DGC |
