Table 3 Results of 25 SNPs previously reported to be associated with CHD in EPIC-CVD

From: A comparison of Cox and logistic regression for use in genome-wide association studies of cohort and case-cohort design

		Subcohort							Case-cohort
			Cox regression			Logistic regression				Cox regression			Logistic regression
rsID	Build 37 chr:pos	N (N cases)	β	SE	P	β	SE	P	N (N cases)	β	SE	P	β	SE	P
rs11206510	chr1:g.55496039T>C	11 812 (437)	0.058	0.088	0.509	0.052	0.092	0.572	18 807 (7432)	0.069	0.036	0.054	0.073	0.031	0.021
rs4299376	chr2:g.44072576T>G	11 697 (436)	−0.020	0.073	0.785	−0.011	0.077	0.885	18 653 (7392)	−0.058	0.030	0.053	−0.043	0.026	0.098
rs2252641	chr2:g.145801461T>C	11 799 (437)	−0.130	0.068	0.057	−0.138	0.072	0.054	18 785 (7423)	−0.019	0.028	0.508	−0.012	0.025	0.639
rs2306374	chr3:g.138119952T>C	11 812 (437)	−0.116	0.090	0.199	−0.125	0.095	0.189	18 806 (7431)	0.008	0.038	0.843	−0.008	0.033	0.821
rs273909	chr5:g.131667353A>G	11 789 (434)	0.012	0.107	0.909	−0.001	0.112	0.996	18 757 (7402)	−0.049	0.043	0.260	−0.065	0.038	0.083
rs2706399	chr5:g.131867702A>G	11 812 (437)	−0.040	0.068	0.552	−0.057	0.071	0.428	18 807 (7431)	0.028	0.028	0.319	−0.015	0.025	0.556
rs9349379	chr6:g.12903957A>G	11 811 (437)	−0.127	0.069	0.066	−0.133	0.073	0.069	18 806 (7432)	−0.093	0.029	0.001	−0.123	0.025	9.00E-07
rs2048327	chr6:g.160863532T>C	11 813 (437)	0.042	0.071	0.553	0.042	0.075	0.578	18 808 (7432)	−0.083	0.030	0.005	−0.092	0.026	4.00E-04
rs2023938	chr7:g.19036775T>C	11 809 (437)	0.000	0.112	1.000	0.001	0.118	0.992	18 802 (7430)	−0.018	0.046	0.691	−0.043	0.040	0.286
rs10953541	chr7:g.107244545C>T	11 810 (437)	0.061	0.081	0.450	0.065	0.084	0.438	18 805 (7432)	−0.009	0.033	0.792	0.015	0.029	0.607
rs264	chr8:g.19813180G>A	11 812 (437)	0.140	0.098	0.151	0.141	0.102	0.168	18 807 (7432)	0.079	0.039	0.040	0.076	0.035	0.029
rs10808546	chr8:g.126495818C>T	11 787 (434)	0.033	0.070	0.632	0.034	0.073	0.642	18 769 (7416)	0.042	0.028	0.142	0.036	0.025	0.149
rs3217992	chr9:g.22003223C>T	11 813 (437)	−0.034	0.070	0.633	−0.036	0.074	0.629	18 808 (7432)	−0.114	0.029	8.00E-05	−0.097	0.025	1.00E-04
rs2047009	chr10:g.44539913G>T	11 811 (437)	0.104	0.068	0.130	0.106	0.072	0.140	18 797 (7432)	0.055	0.028	0.049	0.072	0.024	0.003
rs1746048	chr10:g.44775824C>T	11 811 (437)	0.101	0.104	0.329	0.110	0.108	0.309	18 805 (7432)	0.060	0.042	0.146	0.062	0.036	0.082
rs11203042	chr10:g.90989109C>T	11 813 (437)	0.034	0.069	0.618	0.037	0.072	0.610	18 808 (7432)	0.014	0.028	0.612	0.005	0.025	0.829
rs1412444	chr10:g.91002927C>T	11 812 (437)	−0.118	0.071	0.097	−0.128	0.075	0.086	18 806 (7431)	−0.001	0.030	0.962	−0.041	0.026	0.111
rs974819	chr11:g.103660567C>T	11 324 (424)	−0.123	0.073	0.091	−0.132	0.077	0.086	18 163 (7263)	−0.082	0.031	0.007	−0.080	0.027	0.003
rs964184	chr11:g.116648917C>G	11 811 (437)	0.126	0.103	0.221	0.128	0.108	0.236	18 806 (7432)	−0.047	0.040	0.241	−0.063	0.034	0.065
rs3184504	chr12:g.111884608C>T	11 800 (437)	0.049	0.068	0.472	0.054	0.071	0.447	18 755 (7392)	−0.003	0.028	0.919	−0.014	0.025	0.560
rs9319428	chr13:g.28973621G>A	11 808 (437)	−0.158	0.072	0.027	−0.165	0.075	0.028	18 800 (7429)	−0.050	0.030	0.098	−0.057	0.026	0.030
rs4380028	chr15:g.79111093C>T	11 812 (437)	0.082	0.070	0.241	0.088	0.073	0.229	18 807 (7432)	0.086	0.029	0.003	0.065	0.025	0.010
rs17514846	chr15:g.91416550C>A	11 811 (437)	−0.115	0.068	0.091	−0.112	0.072	0.119	18 796 (7422)	−0.037	0.028	0.187	−0.068	0.025	0.006
rs6511720	chr19:g.11202306G>T	11 813 (437)	−0.067	0.105	0.525	−0.063	0.110	0.568	18 807 (7432)	0.062	0.044	0.156	0.067	0.039	0.089
rs2075650	chr19:g.45395619A>G	11 813 (437)	−0.093	0.099	0.347	−0.099	0.104	0.340	18 808 (7432)	−0.120	0.041	0.003	−0.133	0.036	2.00E-04

N, number of individuals; Build 37 chr:pos, dbSNP (hg19) chromosome:position (risk allele>other allele); β is the logarithm of the association measure (either odds ratio or hazard ratio); SE, standard errors of the logarithm of the association measure (either odds ratio or hazard ratio). In the full case-cohort, the Cox model was Prentice weighted. Alleles are aligned to the + strand.

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Table 3 Results of 25 SNPs previously reported to be associated with CHD in EPIC-CVD

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