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Diallyl sulfide down-regulates polycyclic aromatic hydrocarbon-induced cytochrome P450 1A1 in mouse liver and lung
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  • Published: 01 December 1996

Diallyl sulfide down-regulates polycyclic aromatic hydrocarbon-induced cytochrome P450 1A1 in mouse liver and lung

  • Young-Sook Hong1,
  • Hae-Young Park &
  • Sang-Shin Park 

Experimental & Molecular Medicine volume 28, pages 167–172 (1996)Cite this article

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Abstract

The expression of cytochrome P450 genes directly within target cells is an important determinant of human susceptibility to cancers and other chemically initiated diseases. One pivotal gene, C Y P 1 A 1 codes for an inducible cytochrome P450 isozyme 1A1 responsible for the bioactivation of numerous carcinogenic polycyclic hydrocarbons. In the present study, the effects of 3-methylcholanthrene, a polycyclic aromatic hydrocarbon, on the activity and expression of CYP1A1 and the protective effects of diallyl sulfide on 3-methylcholanthrene-induced changes in mice liver and lung were investigated. After a four daily 3-methylcholanthrene-treatment (25 mg/kg, i.p.), liver and lung microsomal 7-ethoxyresorufin-Odeethylase (EROD) activity, associated with CYP1A1, was increased. A corresponding increase in the level of CYP1A1 mRNA was observed in mouse liver and lung after 3-methylcholanthrenetreatment by Northern blot analysis. Diallyl sulfide reduced 3-methylcholanthrene-induced CYP1A1 mRNA expression and its associated EROD activity in mouse liver and lung. The modulation of CYP1A1 mRNA by 3-methylcholanthrene and diallyl sulfide was mainly due to transcriptional regulation.

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Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, Ewha Womans University, Seoul, 158-056, Korea

    Young-Sook Hong

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  1. Young-Sook Hong
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  2. Hae-Young Park
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  3. Sang-Shin Park
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Hong, YS., Park, HY. & Park, SS. Diallyl sulfide down-regulates polycyclic aromatic hydrocarbon-induced cytochrome P450 1A1 in mouse liver and lung. Exp Mol Med 28, 167–172 (1996). https://doi.org/10.1038/emm.1996.26

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  • Published: 01 December 1996

  • Issue date: 01 December 1996

  • DOI: https://doi.org/10.1038/emm.1996.26

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Keywords

  • diallyl sulfide
  • cytochrome P450
  • carcinogen
  • 3-methylcholanthrene
  • mouse
  • liver
  • lung
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Experimental & Molecular Medicine (Exp Mol Med)

ISSN 2092-6413 (online)

ISSN 1226-3613 (print)

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