Abstract
The peculiarities of helix-coil transition of DNA at complex-formation with cis-diamminedichlorplatinum (II) (cis-DDP) have been investigated in acidic environment by UV absorbance technique. It is shown that observed features of behavior ΔT (pH) and Tm (pH) DNA at pH 2.8-3.0 are possible to explain by formation in DNA of pseudo-ring structures at covalent linking of cis-DDP with DNA.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Dalyan, Y., Haroutiunian, T., Haroutiunian, S. et al. Melting of complexes of DNA-cis-DDP in acidic environment. Exp Mol Med 35, 534–537 (2003). https://doi.org/10.1038/emm.2003.69
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DOI: https://doi.org/10.1038/emm.2003.69
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