Figure 4
Analysis of MDR1 promoter activity in control and mtDNA-depleted HCT-8 cells. Promoter activity of a luciferase reporter gene driven by the MDR1 promoter was measured after transfection of control and mtDNA-depleted cells with pMDR1. Luciferase activity was normalized to Renilla luciferase activity, and shown as fold increase of luciferase activity over the value obtained from the empty pGL3 reporter vector alone. The Results are expressed as the means ± SD of three independent experiments.
