Figure 1
From: Lysophosphatidic acid induces cell migration through the selective activation of Akt1
LPA is a major component of ascites from ovarian cancer patients (AOCP) that induces cell migration. (A) MEF cell migration was induced by the indicated dose of AOCP or ALCP (ascites from liver cirrhosis patients). (B) Migration of MEF cells was induced with LPA (5 µM), AOCP (1%), ALCP (1%), and PDGF (50 ng/ml) in either the presence or absence of LPA receptor antagonist (Ki: Ki16425, 10 µM). *Significantly different from cells stimulated with LPA or AOCP alone (P < 0.05). **Values were not statistically different from cells stimulated with PDGF alone (P > 0.05).
