Figure 5 | Experimental & Molecular Medicine

Figure 5

From: Mutation analysis of PAH gene and characterization of a recurrent deletion mutation in Korean patients with phenylketonuria

Figure 5

Predicted structural changes in human PAH induced by novel mutations. (A) Changing p.Ala202 to threonine is expected to weaken the hydrophobic interactions among Ala202, Tyr198, Tyr206 and p.Leu348. (B) Changing p.Gly344Asp to aspartic acid is expected to distort the backbone interactions among Gly344, Leu347, Glu330, Phe331, Val329, Thr328, and Gly346 over the β4 strand and the α10 helical domain by inducing strong repulsive interactions.

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