Figure 5 | Experimental & Molecular Medicine

Figure 5

From: Liposomal honokiol, a potent anti-angiogenesis agent, in combination with radiotherapy produces a synergistic antitumor efficacy without increasing toxicity

Figure 5

Necrosis and induction of apoptosis assayed by immunohistochemistry with H&E and TUNEL staining, respectively. Representative histological features of LL/2 tumors at 200× magnification were documented. (A-E) TUNEL assay for apoptotic cells. Lipo-HNK (C) and RT (D) treatment groups exhibited an effective induction of apoptosis in tumor tissues compared with NS (A) and Lipo-null (B) groups (P < 0.05). More TUNEL-positive cells were observed in the combination group (E) than in the single treatment Lipo-null and RT groups (P < 0.05). (F-J) H&E for necrosis and blood vessels. Single Lipo-HNK (H), radiotherapy (I) treatment sections revealed a great quantity of necrosis, but less than for the combination of Lipo-HNK and radiotherapy (J). NS (F) and Lipo-null (G) control groups exhibited little necrosis and some of the tumor cells exhibited active proliferation.

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