Figure 6
From: Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis
DF degeneration in hSOD1-G93A mice. Tissues were obtained from hSOD1-G93A mice at end stage and their non-transgenic littermates at the same age. A-D: 100×; E and F: 400×. G: 4000×. A and C: immunohistochemical staining with SMI-31. Asterisks show spongy degeneration of DF in hSOD1-G93A mice. B, D, E and F: toluidine blue staining. G: transmission electron microscopy. Arrows show disaggregated myelin sheath forming ovoids with the central axons disappeared. Asterisks indicate electron-densed axons in DF of hSOD1-G93A mice. The data are representative of all animals examined, at least 3 animals in each group.
