Figure 5
From: Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10
IDO is related to the immunomodulatory effect of MSC culture supernatant on T cells. MLR was done with 5 × 105 splenocytes of BALB/c or C57BL/6 as responder or γ-irradiated stimulator, respectively, for 72 h. In the indicated groups, 1 mM 1-MT was used with or without 100 µl MSC CS in appropriate wells. T cell proliferation was measured by thymidine uptake by T cells. The results shown are expressed as mean ± SD from three independent experiments.
