Figure 4 | Experimental & Molecular Medicine

Figure 4

From: Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy

Figure 4

Effect of AGEs and statin on phosphorylation of MAPK in RASMCs treated with AGEs. Western blot for ERK and p38 in AGEs- or statin-treated RASMCs. The AGEs-treated one revealed increased activation of ERK (A) and p38 (B) and decreased activation with 1 µM of statin. Symbols - and + indicate the absence and presence of AGEs or simvastatin, respectively. Data show a representative gel of ERK and p38 products and a bar graph of data quantitated as relative expression (a.u.) over respective control (mean ± SEM) (n = 5). *P < 0.05 versus control, †P < 0.05 versus AGEs-treated. AGEs, advanced glycation endproducts.

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