Figure 6 | Experimental & Molecular Medicine

Figure 6

From: Potential role of HMG CoA reductase inhibitor on oxidative stress induced by advanced glycation endproducts in vascular smooth muscle cells of diabetic vasculopathy

Figure 6

Effect of statin on suppression of protooncogene, c-jun, and COX-2 mRNA expression induced by AGEs. Expression levels of analysis by RT-PCR. Expression of c-jun (A) and COX-2 (B) revealed increase with AGEs and decrease with statin dose-dependently. Symbols - and + indicate the absence and presence of AGEs or simvastatin, respectively. Data show a representative gel of c-jun and COX-2 products and a bar graph of data quantitated as ratio of protein to its respective GAPDH signal intensity (mean ± SEM) (n = 5). *P < 0.05 versus control; †P < 0.05 versus AGEs-treated. AGEs, advanced glycation endproducts.

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