Figure 2 | Experimental & Molecular Medicine

Figure 2

From: Differential alternative splicing of human transglutaminase 4 in benign prostate hyperplasia and prostate cancer

Figure 2

Comparison of nucleotide and amino acid sequences of human transglutaminase (TG) 4 isoforms. (A) Transglutaminase 4-M2 has four more nucleotide (GTGA, underlined) compare to transglutaminase 4-M1, which results in frameshift. Among three consecutive initiation codons (ATGATGGATG), transglutaminase 4-M1 is translated from first and transglutaminase 4-M2 is from third initiation codon. (B) Deduced amino acid sequence of transglutaminase 4-L. The underlined 45 amino acids are found only in transglutaminase 4-L, not in transglutaminase 4-M or -S. (C) Deduced amino acid sequence of transglutaminase 4-S. Transglutaminase 4-S shows 107 nucleotide deletion compared to transglutaminase 4-M1 and encodes truncated protein comprising 91 amino acids.

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