Figure 4
From: S-Adenosyl-L-methionine ameliorates TNFα-induced insulin resistance in 3T3-L1 adipocytes
SAM inhibited IKK-β kinase activity in a dose-dependent manner. IKK-β and different concentrations of SAM had been preincubated for 10 min and the kinase reaction was allowed to continue for 30 min. IKK-β kinase activity was also measured in the presence of 10 µM staurosporine (Stau), a strong kinase inhibitor. *P = 0.014 by Kruskal Wallace test, *P < 0.001 by ANOVA with posthoc test (n = 3).
