Figure 3 | Experimental & Molecular Medicine

Figure 3

From: Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses

Figure 3

Lung inflammation induced by repeated allergen challenge in combination with dsRNA is dependent upon both IFN-γ- and IL-17-mediated effects, but not on IL-13. Evaluation (n = 5 per group) was performed 48 h after the final allergen challenge. PBS, mice sensitized with OVA and then challenged with PBS; IC/OVA, mice sensitized and then challenged with OVA + poly(I:C). (A) BAL cellularity in IFN-γ-deficient and WT (both BALB/c background) mice. (B) The levels of IP-10 and TGF-β1 (left panel) and TNF-α (right panel) in the BAL fluids of IFN-γ-deficient and WT mice. (C) BAL cellularity in the IL-17A-deficient and WT (both BALB/c background) mice. (D) The levels of IP-10 and TGF-β1 (left panel) and TNF-α (right panel) in the BAL fluids of IL-17A-deficient and WT mice. (E) BAL cellularity in the IL-13-deficient and WT (both C57BL/6 background) mice. (F) Levels of IP-10 and TGF-β1 (left panel) and TNF-α (right panel) in the BAL fluids of the IL-13-deficient and WT mice. For all figures, *, P < .05 compared to the PBS groups; **, P < .05 compared to the other groups.

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