Figure 5 | Experimental & Molecular Medicine

Figure 5

From: Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses

Figure 5

Virus-associated severe inflammation in the lung is abolished in the absence of iNOS gene expression. In all the experiments, evaluation (n = 5 per group) was performed 48 h after the final allergen challenge; PBS, mice sensitized with OVA and challenged with PBS; IC/OVA, mice sensitized and challenged with OVA + poly(I:C); *, P < .05 compared to the PBS groups; **, P < .05 compared to the other groups. (A) BAL cellularity in iNOS-deficient and WT (both C57BL/6 background) mice. (B) Representative lung histologies (a and c, WT_IC/OVA; b and d, iNOS KO_IC/OVA; H&E staining; a and b: original magnification × 200; c and d: original magnification × 400). (C) Levels of IP-10 and TGF-β1 (left panel) and TNF-α (right panel) in the BAL fluids from iNOS-deficient and WT mice.

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