Figure 6 | Experimental & Molecular Medicine

Figure 6

From: Role of inducible nitric oxide synthase on the development of virus-associated asthma exacerbation which is dependent on Th1 and Th17 cell responses

Figure 6

Treatment with a specific iNOS inhibitor (1400 W) abolishes lung inflammation induced by repeated allergen challenge with dsRNA. Evaluation (n = 5 per group) was performed 48 h after the final allergen challenge; PBS, mice sensitized with OVA and then challenged with PBS; IC/OVA, mice sensitized and challenged with OVA + poly(I:C); *, P < .05 compared to PBS; **, P < .05 compared to the other groups. (A) BAL cellularity in mice treated with different doses (1 and 5 mg/kg) of 1400 W. (B) Representative lung histologies of mice treated with 1400 W (a, PBS; b, IC/OVA_sham; c, IC/OVA_1400 W (1 mg/kg); d, IC/OVA_1400 W (5 mg/kg); H&E staining, original magnification × 400). (C) Levels of IP-10 and TGF-β1 (left panel) and TNF-α (right panel) in the BAL fluids from mice treated with 1400 W.

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