Figure 4 | Experimental & Molecular Medicine

Figure 4

From: Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells

Figure 4

PKCα modulate HO-1 expression in CC cells. (A) Immunoblot analysis of Bach1, PKCα, phosphorylated PKCα, and HO-1 expression in the four CC cell lines. (B) Higher expression of PKCα (red) in SCK cells than in Choi-CK cells. Immunoreactivity was assayed by immunofluorescence. Trans, transmission. Bar, 20 µM. (left panels). (C) Nuclear Nrf2 and subsequent HO-1 expression was enhanced by PKCα in Choi-CK cells. The cells were transiently transfected with PKCα or constitutively active MyrPKCα, and their respective nuclear (Nucl) and cytoplasmic (Cyto) lysate fractions were subjected to immunoblot anlayses for Nrf2 and HO-1.

Back to article page