Figure 3 | Experimental & Molecular Medicine

Figure 3

From: p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb

Figure 3

p41-Arc induces senescence in p53-deficient tumor. (A) SA-β-gal staining and morphology 6 days after infection with tTA-encoding adenovirus in SaOs-2 and its stable transfectants harboring ptet-p41. (B) Proportion of SA-β-gal stained cells. The cells as in (A) were washed and fixed with 0.25% glutaraldehyde in PBS for 15 min at room temperature and stained at pH 6.0 as described in Materials and Methods. (C) Expression of p21 and p27 in SaOs-2 cells and its transfectants harboring ptet-p41 infected with tTA-virus.

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