Figure 4 | Experimental & Molecular Medicine

Figure 4

From: Myeloid differentiation primary response protein 88 blockade upregulates indoleamine 2,3-dioxygenase expression in rheumatoid synovial fibroblasts

Figure 4

MyD88 blockade increases IDO induction in synovial fibroblasts after stimulation with LPS. Rheumatoid synovial fibroblasts were transfected with MyD88 siRNA or scrambled siRNA. After 24 h, transfected fibroblasts were stimulated with LPS (1 µg/ml) for 5, 15, 30 min, and 24 h. IκB phosphorylation (A) IDO, MyD88 or TRIF mRNA (B) expressions were examined by western blotting or real time RT-PCR, respectively. Data are presented as means ± SD of replicate samples in one of three experiments. *P < 0.05 and **P < 0.01, MyD88-transfected vs. scrambled-transfected cells.

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