Figure 3 | Experimental & Molecular Medicine

Figure 3

From: JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Figure 3

Anti-calretinin staining showed altered expression levels and developmental defects in thalamocortical fibers in the brains of jsap1-/-. (A-V) Anti-calretinin stained coronal sections of the cortices of developing brains at E14.5 (A-H), E16.5 (I-N) and E17.5 (O-V). Anti-calretinin immunoreactivity in jsap1-/- brains at E16.5-17.5 was reduced in many brain regions compared to jsap1+/+ brains (I-V). Anti-calretinin labeled thalamocortical fibers (arrows) in jsap1-/- brains at E16.5-17.5 appeared to have a pathfinding defect (M, N, S-V). High magnification of the panels S and T (U, V). cng, cingulum bundle; CP, caudo-putamen; CxP, cortical plate; hn, hippocampal neuroepithelium; ic, internal capsule; IZ, intermediate zone; ec, external capsule; LV, lateral ventricle; MZ, molecular zone; SP, subplate; tca, thalamocortical axons; VZ, ventricular zone. Scale bars, 500 µm.

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