Figure 4 | Experimental & Molecular Medicine

Figure 4

From: JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains

Figure 4

Reduced expression of phospho-FAK levels in developing brains of jsap1-/-. (A-H) Anti-phospho-FAK stained coronal sections of cryo-cut brains at E14.5 (A, B), E16.5 (C, D), and E17.5 (E-H). Phospho-FAK was distributed in the soma and neuritic processes of neuronal cells in broad regions in the developing jsap1+/+ and jsap1-/- brains. The expression level of phospho-FAK in the U-shaped axon tract of the corpus collasum (C-F) and anterior commissure (G, H) in jsap1-/- brains was lower than that in jsap1+/+ brains. (I) Quantification of the expression levels of phospho-FAK in indicated brain regions in both genotypes. The pixel density of immunoreactivity was measured, as described in Materials and Methods. *, P < 0.05 and **, P < 0.01, differences between jsap1+/+ and jsap1-/- brains (Student's t-test). AC, anterior commissure; CC, corpus callosum; CxP, cortical plate; IZ, intermediate zone; LV, lateral ventricle; MZ, molecular zone; Pb, Probst's bundle; VZ, ventricular zone. A, C, and E; jsap1+/+. B, D, and F; jsap1-/-. Scale bars, 500 µm.

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