Figure 1
From: Grape seed proanthocyanidin extract ameliorates monosodium iodoacetate-induced osteoarthritis
Effects of GSPE on the pain in MIA-induced OA. An experimental model of OA in rats was induced by intraarticular injection of monosodium iodoacetate (MIA) into the knee joint. Oral treatment with GSPE (100 mg/kg or 300 mg/kg given three times per week) or with vehicle was initiated on MIA injection (day 0). (A) The paw withdrawal latency and (B) paw withdrawal threshold were measured by a dynamic plantar aesthesiometer and this was compared with that of the MIA-treated group. △: nonarthritis group, ▲: MIA-treated group, ◇: MIA-treated rats treated with 300 mg/kg GSPE. *P < 0.05, **P < 0.01 compared with the MIA injection group. (C) Weight bearing was measured by an incapacitance tester and this was compared with that of the MIA-treated group at 4 weeks after the injection of MIA. *P < 0.05 compared with the MIA injection group. The experiment was repeated 3 times with similar results.
