Figure 4

Histological analyses of wound healing. Masson's Trichrome-stained sections of wounds (A) at a low magnification and (B) at a high magnification at 12 days after treatment with PRP + various delivery systems. The dotted squares indicate the mid portion used in (B). Ep, epithelium; De, dermis; h, hair follicle; Gr, granulation tissue; Mu, muscle layer; Sc, subcutaneous tissue; St, scar tissue; He, hypertrophic epithelium. (C) Graphic illustration of wound healing. (D) Wound edge distance (i.e., distance between tips of epithelium), hypertrophic coverage, and inter-SC distance in wounds at 12 days after treatment with PRP + various delivery systems. *P < 0.001 compared to F-PRP or HCF-PRP. **P < 0.05 compared to HCF-PRP.