Figure 5
In vivo efficacy of anti-EpCAM mAb for inhibition of tumor growth in nude mice. (A) Differential volume (size) and morphology of inhibited tumor. (B) Tumor volumes (size) were recorded at 7, 14, 21, and 28 days after injection. (C) Tumor weight was recorded after excision. SW620 human colon cancer cells (2 × 106) were injected subcutaneously (s.c.) into each mouse (thymus-deficient BALB/c nu/nu mice). After tumor cell inoculation, each experimental group of 10 mice received i.p. injections of anti-EpCAM mAb, and DNR as a positive control, respectively (100 µg of the mAb every 2 days).
