Figure 1
From: The discovery of placenta growth factor and its biological activity
Schematic representation of binding properties of PlGF isoforms and PlGF/VEGF heterodimer. The possible dimers formed by PlGF monomer (gray) are represented. In the case of PlGF isoforms 2 and 4, the heparin-binding domain is represented by additional filled oval. For the heterodimer, the VEGF moiety is in orange. For VEGF receptors (green VEGFR-1, yellow VEGFR-2) the seven Ig-like domains are represented as half ovals, whereas filled rectangles represent the intracellular TK domains. The extracellular Neuropilins receptor 1 and 2 domains are represented as vertical ovals (domains ai, a2), square (b1, b2) and an horizontal oval (domain c) (Mamluk et al., 2002). Heparan sulfate is represented in red.
