Figure 1

Location of the SNPs on the EGR2 gene and the linkage disequilibrium structure of the locus. Graphic representation of the genomic structure and location of the EGR2 SNP sites examined and the linkage disequilibrium (LD) structure of the EGR2 haplotype block. Exons are denoted by boxes, with untranslated regions in white and translated regions in gray. The LD between SNPs was analyzed using the pair-wise LD measures D' and r² and the haplotype block was constructed using the solid spine haplotype algorithm (D' > 0.8). Each diamond either represents the D' or r² measure of LD (D': darker shades of red represent greater D' values, r²: darker shades of black represent greater r² values).