Figure 7 | Experimental & Molecular Medicine

Figure 7

From: Syringaresinol causes vasorelaxation by elevating nitric oxide production through the phosphorylation and dimerization of endothelial nitric oxide synthase

Figure 7

Schematic proposal for the mechanism responsible for syringaresinol-induced vasorelaxation. Syringaresinol activates both PLC and PI3K, which induce intracellular Ca2+ mobilization and Akt, respectively. Increased intracellular Ca2+ level promotes eNOS dimerization and CaMKKβ/AMPK responsible for eNOS phosphorylation. In addition, the PI3K/Akt pathway promotes eNOS phosphorylation. These biochemical events result in an increase in eNOS-dependent NO synthesis and subsequent activation of sGC in smooth muscle cells to synthesize cGMP from GTP, leading to vascular relaxation.

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