Figure 6 | Experimental & Molecular Medicine

Figure 6

From: Parthenolide-induced apoptosis of hepatic stellate cells and anti-fibrotic effects in an in vivo rat model

Figure 6

Anti-fibrotic effects of PT in TAA-treated rats. (A) Representative microscopic images of rat liver, hematoxylin and eosin staining (upper panels), Masson-trichrome stain (middle panels), and immunohistochemical staining for α-SMA in rat liver (lower panels). (B) Histopathologic score obtained using Scheuer's scoring system as described in the 'Materials and Methods'. Treatment groups: I, control; II, TAA; III, TAA+PT2; IV, TAA+ PT4. (C) PT inhibited TAA-induced TGF-β1 expression as shown by Western blot analysis. TAA, thioacetamide; PT2, parthenolide 2 mg/kg; PT4, parthenolide 4 mg/kg. (D) TUNEL staining and GFAP immunostaining showed co-localization of TUNEL positives and GFAP immunoreactivities in hepatic HSCs from the liver tissue of rats treated with TAA and PT4 (× 400).

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