Figure 4 | Experimental & Molecular Medicine

Figure 4

From: A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-β1-induced MMP-1 and MMP-9 expression in breast cancer cells

Figure 4

Activation of downstream signaling molecules of receptor by HRG were significantly increased in HER2-overexpressed MCF7 cells. After serum-starvation for 24 h, cells were treated with or without 50 ng/ml HRG for 30 min. The phosphorylation of HER3, HER2, ERK, JNK, Akt, c-Jun, and β-actin was determined in whole cell lysates by Western blotting. The results shown are representative of three independent experiments.

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