Figure 1

Photomicrographs showing the 6-grade photographic plaque reference panels for four selected regions in the brains of Tg2576 mice (plate A or Tg2576 panels). (A-D) The 6-grade photographic plaque reference panels named "plate A or Tg2576 panels" showing plaque depositions in the prefrontal cortex (A, 0-6), hippocampus (B, 0-6), parietal cortex (C, 0-6), and piriform cortex (D, 0-6) of Tg2576 mice. Photomicrographs for each region were chosen to represent an increasing number of plaques over the grading scales. In practice, a 0.5-interval grade at any level may be used. For example, when the level of plaque deposition is higher than +2, but lower than +3, a +2.5 grade may be given. Scale bar in A-D; 500 µm.