Figure 7

Triptolide inhibited tumor formation in nude mice. (A) SKOV3 cells were injected subcutaneously into nude mice. Triptolide at 0, 0.1, 0.3 or 1 mg/kg/day was orally administered daily for three weeks, and tumor xenografts were removed and weighed. ^*P < 0.05 comparing to untreated mice. (B) Protein lysates were prepared from tumors. MMP7, MMP19 and E-cadherin were detected by Western blot. (C) SKOV3 cells were injected (i.p.) into nude mice. Triptolide at 0 and 1 mg/kg/day was orally administered daily for five weeks, and metastasis nodules were examined and quantified. ^*P < 0.05 comparing to untreated mice.