Figure 2

The contextual memory deficit of Tg-APP/PS1 mice was reversed by NIa expression. The entry latency into the dark chamber for Tg-APP/PS1 mouse control (Tg-CON), Tg-APP/PS1 mice infused with Lenti-NIa (Tg+NIa), and their non-transgenic control (WT) in the passive avoidance test. The latency to enter into the dark chamber after shock (post-shock) is used as an indicator of learning and memory. Two-way repeated measures ANOVA and Bonferroni post-hoc test for data groups at post-shock days: significant difference between animal groups [F_(2,46) = 11.34, P < 0.001], time [F_(2,46) = 10.08, P < 0.001], but no animal group × time interaction [F_(4,46) = 0.3358, P = 0.8524]; ^* and ^** denote differences between WT and Tg-CON at P < 0.05 and P < 0.01, respectively; ^# and ^## denote difference between Tg-CON and Tg+NIa at P < 0.05 and P < 0.01, respectively. Data are presented as the means ± SEM. Numbers of animals used: WT, 5 males and 5 females; Tg-CON, 4 males and 4 females; Tg+NIa, 4 males and 4 females.