Figure 1 | Experimental & Molecular Medicine

Figure 1

From: Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase

Figure 1

Effects of K+ channel inhibitors on the resting tone of mesenteric arterial rings. (a) Typical traces of mesenteric artery constriction responding to the K+ channel inhibitor 4-aminopyridine (4-AP, 10 mM), the Ca2+-activated K+ (BKCa) channel inhibitor iberiotoxin (IbTX, 120 nM), the ATP-sensitive K+ (KATP) channel inhibitor glybenclamide (Gly, 10 μM) and the inwardly rectifying K+ (Kir) channel inhibitor BaCl2 (100 μM). (b) A summary of the vasoconstrictive effects of the K+ channel inhibitors. TEA, tetraethylammonium. Numbers in parentheses indicate the number of arterial rings tested. *P<0.05, **P<0.01 and ***P<0.001 versus resting values.

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