Figure 3 | Experimental & Molecular Medicine

Figure 3

From: Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase

Figure 3

The effects of 5-hydroxytryptamine (5-HT) and α-methyl 5-HT on voltage-gated K+ (Kv) currents. (a, e) Representative recordings of K+ currents in the absence and presence of 5-HT (1 μM) or α-methyl 5-HT (1 μM). The shape of the voltage pulse protocol used to elicit the Kv currents is shown as a figure inset. (b, f) Current–voltage (I–V) relationships in the absence and presence of 5-HT (1 μM) or α-methyl 5-HT (1 μM). 5-HT and α-methyl 5-HT reduced Kv currents to similar degrees. (c, d) The effect of tetraethylammonium (TEA; 1 mM) plus glybenclamide (1 μM) pretreatment on the inhibiting effect of 5-HT on the K+ currents. *P<0.05 versus the control. **P<0.01 versus the control.

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