Table 1 Bioactive molecules used for in situ tissue regeneration
From: In situ tissue regeneration through host stem cell recruitment
Stem cell-inducing/stimulating factor |
Substance P (SP) |
Granulocyte-colony-stimulating factor (G-CSF) |
CXCR4 antagonist (AMD3100) |
Stem cell factor (SCF) |
Parathyroid hormone |
Stem cell-homing/migration factor |
Stromal cell-derived factor-1 (SDF-1) |
Protease-resistant SDF-1α |
SDF-1α inhibitors |
Diprotin A (inhibition of SDF-1α inhibitor (Dipeptidyl eptidase IV)) |
Hepatocyte growth factor (HGF) |
Monocyte chemotactic proteins (MCPs) |
Matrix metalloproteinase-2 (MMP-2) |
Galanin |
Collagen synthase inhibitors |
Matrix metalloproteinase inhibitors (MMPs) |
Propyl hydroxylase |
C-proteinase inhibitor |
Halofuginone |
Tissue-enhancing factors |
Transforming growth factor-βs (TGF-βs) |
Insulin-like growth factors (IGFs) |
Fibroblast growth factor-1 (FGF-1) |
Epidermal growth factor (EGF) |
Angiogenic factors |
Vascular endothelial growth factor (VEGF) |
Fibroblast growth factor-2 (FGF-2) |
Platelet-derived growth factor-BB (PDGF-BB) |
TGF-βs |
Angiogenin |
Angiopoietin-1 (Ang-1) |
Angiopoietin-2 (Ang-2) |
Delta-like ligand 4 (Dll4) |
Innervation factors |
Brain-derived neurotrophic factor (BDNF) |
Glial cell line-derived neurotrophic factor (GDNF) |
Nerve growth factor (NGF) |
Agrin |
