Figure 1
From: Recent advance in brown adipose physiology and its therapeutic potential
Cellular origins of brown adipocytes. At least three cellular origins of brown adipocytes exist, all featuring distinct developmental stages and anatomical locations. (1) During developmental growth, constitutive brown adipocytes are generated from Myf5+ cells, the common progenitors of brown adipocytes and myocytes in skeletal muscle. (2) Beige adipocytes found in gonadal WAT originate from PDGFRα+ progenitors, which have been identified as the common progenitors of white and brown adipocytes. (3) Mature white adipocytes can be converted into beige adipocytes in subcutaneous WAT during cold stress.
