Figure 3 | Experimental & Molecular Medicine

Figure 3

From: Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice

Figure 3

Effects of Janus-activated kinase 3 (JAK3) suppression on cardiomyocyte apoptosis. Hearts were retrieved 24 h after reperfusion and subjected to TUNEL (terminal deoxynucleotide transferase-mediated deoxyuridine triphosphate nick-end labeling) staining. (a) Representative TUNEL staining is shown. (b) The numbers of TUNEL-positive nuclei are expressed as percentages of total nuclei. (c) Hearts were retrieved 12 h after reperfusion and the expression levels of Bax and cleaved caspase-3 and -9 were examined by western blot analyses. Values are the mean±s.e.m. of three independent experiments (n=8–9 mice per group). **P<0.01 vs sham; ## P<0.01 vs ischemia/reperfusion (I/R)-operated wild-type (WT) mice.

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