Table 1 miRNAs linked to SSc fibrosis
miRNA | Effect | Tissue examined | Target gene and protein | References |
|---|---|---|---|---|
miR-29 | Antifibrosis | SSc fibroblasts, bleomycin-induced skin fibrosis | COL1A1, COL1A2, COL3A1, FBN1, ELN1, ECM synthesis | 10, 23–26, 43–45 |
miR-21 | Profibrosis | SSc skin tissues, SSc fibroblasts | Smad7 | 10 |
miR-150 | Antifibrosis | SSc fibroblasts | Integrin-β3 | 46 |
miR-196a | Antifibrosis | SSc fibroblasts | COL1A1, COL1A2 | 47, 48 |
miR-92a | Profibrosis | SSc fibroblasts | MMP-1 | 49 |
