Table 1 Major neurodegenerative disorders related to mtDNA mutation
From: The role of mitochondrial DNA mutation on neurodegenerative diseases
Disease | Major effective molecule | Function | References |
|---|---|---|---|
Alzheimer’s disease | β-Amyloid | Defecting BER pathways. Altering calcium homeostasis. | Cha et al.49 Reddy et al.50 Canugovi et al.51 Krishnan et al.52 |
Parkinson’s disease | Parkin | Resulting in a defective assembly of the OXPHOS complex. | Winklhofer et al.53 Jin et al.54 Sterky et al.55 Liu et al.56 Tufi et al.57 |
Amyotrophic lateral sclerosis | SOD1 | Binds to VDAC1. Increasing oxidative damage to mtDNA. | Murakami et al.60 Israelson et al.61 Dhaliwal et al.62 Warita et al.63 Kikuchi et al.64 |
Huntington’s disease | Huntingtin | Reducing respiratory chain complex function. Generating ROS. | Ayala et al.65 Oliveira et al.66 Siddiqui et al.67 Wang et al.68 |
