Figure 1
The microRNAs (miRNAs) that show post-learning dysregulation in Baf53b+/− mice regulate actin remodeling via Cofilin. This schematic depicts the proposed model for how regulators of the actin cytoskeleton in dendritic spines are influenced by the loss of BAF53b. The influx of calcium through the N-methyl-D-aspartate (NMDA) receptor directly and indirectly activates small GTPase exchange factors, activating RhoA, Rac1 and Cdc42 and leading to the accumulation of pCofilin in neuronal spines. Following this stimulation, miR132 and miR134 can regulate the level of pCofilin. The red circles indicate post-learning upregulation in wild-type mice, while the blue circles indicate post-learning downregulation in Baf53b+/− mice. Yellow circled p, phosphorylation.
