Table 1 Diverse functional interactions of APE1/Ref-1 with various proteins

From: APE1/Ref-1 as an emerging therapeutic target for various human diseases: phytochemical modulation of its functions

Sr. no.

Interacting protein (reference)

APE1

 BER proteins

1

XRCC113

2

DNA ligase IIIα236

3

Pol β237

4

FEN115, 236

5

GADDα modulates APE1 activity by directly interacting with PCNA238

6

PCNA15

7

PARP1239

8

GAPDH240

 Transcriptional proteins

1

Egr-121

2

NF-κB132

3

p5321

4

HIF-1α21

5

CREB21

6

AP-1 (c-Jun)21

7

Pax-821

8

STAT37, 161

9

p3007

10

HDAC17

 Other proteins

1

YB-124

2

anti-NGF 3026

3

PKM226

4

hn-RNA-H26

5

Tmod326

6

N-acetyltransferase CML126

7

Sphingosine 1-phosphate phosphatase 1 isoform26

8

Leucine-rich and death domain-containing26

9

Tropomyosin alpha-3 chain isoform 126

10

Sulfotransferase 1C226

11

NPM192

12

HSP70121

13

Nm23-H1241

14

SIRT1 protein deacetylase242

15

Bcl2243

  1. Abbreviations: anti-NGF 30, anti-nerve growth factor 30 antibody heavy-chain; AP-1, activator protein 1; APE1, apurinic/apyrimidinic endonuclease 1; BER, base excision repair; CREB, cAMP response element-binding; FEN1, Flap endonuclease 1; GADDα, growth arrest and DNA damage alpha; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HDAC1, histone deacetylase 1; HIF-1α, hypoxia inducible factor 1α hn-RNA-H1, heterogeneous nuclear ribonucleoprotein-H1; HSP70, human heat shock protein 70; NF-κB, nuclear factor kappa B; Nm23-H1, non-metastatic protein-23 homolog-1; NPM1, nucleophosmin; PARP1, poly (ADP-ribose) polymerase 1; PCNA, proliferating cell nuclear antigen; PKM2, pyruvate kinase 3 isoform 2; Ref-1, redox effector factor-1; SIRT1, SIRTUIN1; STAT3, signal transducer activator of transcription 3; Tmod3, tropomodulin 3; XRCC1, X-ray cross complementation protein 1.
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