Table 2 Allele and genotype frequencies of MBL2 gene polymorphisms in study subjects

From: Effects of MBL2 polymorphisms in patients with diisocyanate-induced occupational asthma

    

aP-value

 

DI-OA (n=99)

AEC (n=99)

NC (n=144)

DI-OA vs AEC

DI-OA vs NC

DI-exposed vs NC

−554 G/C (rs11003125)

 GG

33 (33.33%)

30 (30.3%)

37 (25.69%)

0.789

0.281

0.541

 GC

40 (40.4%)

46 (46.46%)

76 (52.78%)

0.711

0.811

0.964

 CC

26 (26.26%)

23 (23.23%)

31 (21.53%)

0.702

0.166

0.308

 q

0.465

0.465

0.479

0.979

0.454

0.530

−431A/C (rs11003124)

 AA

88 (88.89%)

75 (75.76%)

114 (79.17%)

0.016

0.214

0.239

 AC

8 (8.08%)

24 (24.24%)

26 (18.06%)

0.999

0.396

0.090

 CC

3 (3.03%)

0 (0%)

4 (2.78%)

0.016

0.080

0.606

 q

0.071

0.121

0.118

0.081

0.058

0.303

−225 G/C (rs7096206)

 GG

81 (81.82%)

70 (70.71%)

113 (78.47%)

0.169

0.554

0.716

 GC

17 (17.17%)

27 (27.27%)

27 (18.75%)

0.550

0.490

0.450

 CC

1 (1.01%)

2 (2.02%)

4 (2.78%)

0.060

0.314

0.925

 q

0.096

0.157

0.122

0.064

0.258

0.876

  1. Abbreviations: AEC, asymptomatic exposed control; DI-OA, diisocyanate-induced occupational asthma; NA, not applicable; NC, normal control; n, number of subjects; q, minor allele frequency.
  2. Logistic regression analysis was applied to control for age and sex as covariates.
  3. The values in bold indicate significant P-values. Each P-value <0.05 was considered to be significant.
  4. aEach P-value was calculated using the co-dominant, dominant and recessive models.
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