Figure 3 | Experimental & Molecular Medicine

Figure 3

From: Myeloid deletion of SIRT1 suppresses collagen-induced arthritis in mice by modulating dendritic cell maturation

Figure 3

Phenotypes of the T cells and DCs and levels of anti-type II collagen (CII) antibodies in the CIA mouse model. The regional lymph nodes were harvested on Day 28, and the sera were collected on Day 39 from the mSIRT1 KO (KO) and wild-type (WT) mice with CIA. The T cell and DC phenotypes were determined by flow cytometry, and the levels of anti-CII antibodies were measured by enzyme-linked immunosorbent assay. (a) Dot plots (left panel) and proportions (right panel) of Th1 and Th17 cells. (b) The serum levels of IgG2a and IgG1 and IgG2a-to-IgG1 ratio were determined. (c) Histogram (left panel) and proportions (right panel) of CD80- and CD86-positive DCs. The values are expressed as the means±s.e. (4–8 mice per group), *P<0.05, **P<0.01 vs WT.

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