Figure 1
From: The macrophage migration inhibitory factor protein superfamily in obesity and wound repair
(a) MIF in adipose tissue. MIF is secreted from mature adipocytes, preadipocytes and ATMs. It promotes the adipogenesis of preadipocytes and increases the size and number of mature adipocytes. MIF further directs ATMs into an M1 polarization status and acts as a chemoattractant. MIF contributes to chronic adipose tissue inflammation, obesity and impaired glucose homeostasis. (b) D-DT in adipose tissue. D-DT is secreted from mature adipocytes and ATMs promotes adipogenesis of preadipocytes. D-DT is downregulated in adipose tissue from obese individuals and improves glucose intolerance. ATM, adipose tissue macrophages; D-DT, D-dopachrome tautomerase; MIF, migration inhibitory factor.
