Figure 2
From: CTCF as a multifunctional protein in genome regulation and gene expression
CTCF and the cohesin complex can lead to transcriptional activation or repression in a binding site-dependent manner. For example, when CTCF and cohesin bind to their binding sites and create a chromatin loop that encompasses the enhancer and promoter, transcriptional activation occurs. Conversely, if CTCF and cohesin form a chromatin loop that prevents the enhancer from reaching the promoter, gene expression is repressed. CTCF, CCCTC-binding factor.
